jackman/biol125-lectures
1
0
Fork 0
Code Issues Pull Requests Releases Wiki Activity

pain

Browse Source
This commit is contained in:
ackman678
2021-11-03 11:57:39 -07:00
parent 34a89e0932
commit a75e1d2ea8
3 changed files with 25 additions and 16 deletions
Download Patch File Download Diff File Expand all files Collapse all files

16
neurotransmitters3.md
View File

@@ -42,12 +42,12 @@ This Ca^2+^ permeability depends on subunit composition of the nAchR pentamer. m
from [#Picciotto:2000]:
from [^Picciotto:2000]:
>some subtypes of nAChR in the brain (those containing the b2 subunit) are located diffusely throughout the membrane of the neuron, with no obvious concentration at the synaptic junction (Hill et al. 1993).
https://us02web.zoom.us/j/86077044985?pwd=USt1SGJ6Wm1VSitncWlmTjgzSmZrQT09
a number of alpha and beta subunits have expression throughout brain (medulla, superior colliculus, cortex, beta2 subunit expression 'very high' in thalamus). Only alpha3 KO mice have high mortality [#Picciotto:2000].
[#Picciotto:2000]: Picciotto, M. R., Caldarone, B. J., King, S. L., and Zachariou, V. (2000). Nicotinic receptors in the brain. Links between molecular biology and behavior, Neuropsychopharmacology, 22(5), 451-65. PMID 10731620
[^Picciotto:2000]: Picciotto, M. R., Caldarone, B. J., King, S. L., and Zachariou, V. (2000). Nicotinic receptors in the brain. Links between molecular biology and behavior, Neuropsychopharmacology, 22(5), 451-65. PMID 10731620
Low (nM) concentrations of nicotine are found in the blood of moderate smokers (Henningfield et al. 1983). These are sufficient to enhance excitatory transmission in cultures of neurons from the medial habenula or the hippocampus (Gray et al. 1996; McGehee et al. 1995) [#Picciotto:2000]
@@ -117,7 +117,9 @@ Ligand gated channels in general are made up of 4 or 5 subunit monomers.
* 5 or so isoforms
* mAChR blockers are used for pupil dilation (atropine), motion sickness (scopolamine) and asthma treatment (ipratropium)
<div><img src="figs/2006-10-25_Amanita_muscaria_crop_copy_6b3de79.jpg" height="200px"><figcaption>[*Amanita muscaria*, Onderwijsgek, CC BY-SA 3.0 nl](https://commons.wikimedia.org/w/index.php?curid=21983879)</figcaption></div>
<div><img src="figs/2006-10-25_Amanita_muscaria_crop_copy_6b3de79.jpg" height="200px"><figcaption>
[*Amanita muscaria*, Onderwijsgek, CC BY-SA 3.0 nl](https://commons.wikimedia.org/w/index.php?curid=21983879)</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-06.04-1R_copy_e029b6f.jpg" height="200px"><figcaption>Neuroscience 5e Fig. 6.4</figcaption></div>
@@ -204,10 +206,10 @@ GluR1 | GluR5 | NR1 | mGluR1
GluR2 | GluR6 | NR2A | mGluR5
GluR3 | GluR7 | NR2B | mGluR2
GluR4 | KA1 | NR2C | mGluR3
| KA2 | NR2D | mGluR4
| | NR2D | mGluR6
| | NR3A | mGluR7
| | NR3B | mGluR8
GluR5 | KA2 | NR2D | mGluR4
| | NR2D | mGluR6
| | NR3A | mGluR7
| | NR3B | mGluR8
</div>