* main.md contains latest from brmullen, scweiser gdoc vers <https://docs.google.com/document/d/1VU3gaRKq3z3dN8ZNvDmwCUXAtIp4xkUgb4xXx5mhGvM> - that version was in turn a merged version from the biorxiv manuscripts contained in the methods-paper.git and ML-paper.git repos from 2020-2021 * jba added comments.md